Jacob’s art tackles contemporary understanding of complex scientific issues, as well as notions of inheritance, ancestry, legacy and the self. He has completed several major permanent ceramic installations: at Chatsworth House in 2014 he created The North Sketch Sequence, an immersive work in handmade ceramic panels that depicts the DNA of the Duke and Duchess of Devonshire. More recently Jacob completed a significant ceramic installation called The DNA Room for The Dutch State. Alain de Botton has said of his work “A beautiful poetic work which is exemplary in the way it manages to turn information (of which we have so much, and which usually leaves us so cold) into art (which touches our hearts)”.
Jacob has been artist-in-residence at The Wallace Collection, The Wellcome Sanger Institute, a renowned world leading genomics centre and in 2024 held a solo show at New Art Centre, Roche Court. Jacob trained with esteemed artist and author Edmund de Waal in 2004 and his work is held in numerous museum collections and collected internationally.